Dosage forms that demonstrate local and systemic reactions when administered via other routes of delivery can now be administered effectively via the oral cavity (49). Moreover, drug formulations which are basic in nature demonstrated high stability within the oral cavity due to the neutral PH provided by the saliva and mucus (13). Patients also have the ability to self-administer drug doses and have the free will to terminate the drug intake by simply spitting or swallowing the tablet following oral route drug administration (49).
The Oral and Buccal Cavity as Drug Delivery Sites
According to Liang, Peng, Zhou, Zou, and Cheng (7), mucoadhesion have also been shown to prolong the dosage forms’ retention time at the application site for the effective delivery of these agents. Moreover, patients were shown to comply with medication due to the elimination of pain and the sustained release of the drugs (6). Drugs are also able to achieve a rapid onset of action, thus serving as faster drug delivery channels (The purpose of this thesis is not absorption because we are not looking for a systemic effect, only local treatment in the oral cavity – so maybe we shoul remove this sentence or write it differently?) (6). Nonetheless, Hua (8) further noted that some dosage forms demonstrated local and systemic reactions when administered via other routes of delivery and could only be effectively delivered when administered via the oral cavity.