Probiotics have effects in boosting the immune system (20, 21) and can also enhance the activity of several immune cells such as the natural killer cells (4). Vicekananda, Vandana, and Bha (22) however posited that probiotics played essential roles in the reduction of the index of gingivitis. This action can be correlated to the effects of probiotics in the reduction of plaque scores as evident in a study conducted by Vicario, Santos, Violant, Nart and Giner (23). Hoffmann and Daniels (4) added that dental caries was associated with Lactobacillus and S. mutans bacterial strains. However, contradictory findings were elaborated in a study conducted by Smark-Mattison et al. (5), where patients free of dental carries exerted more effective inhibitory effects against mutant forms of Streptococci than Lactobacilli that was isolated from patients with dental caries. Washington, Washington and Wilson (24) ascertained that probiotic bacteria were instantaneously released from the probiotic orally disintegrating tablets (ODTs) at the action sites but was affected by the resident time in the oral cavity as a result of the constant flashing demonstrated by the reaction of saliva alongside drinking and eating.