Probiotics have been shown to replenish the natural flora within the oral cavity, including other bacterial species such as the Streptococci and the Staphylococcus bacteria (50). Iannitti and Palmieri (51) added that the probiotics had to adhere to the oral and buccal cavity cells for the promotion of co-aggregation and the induction of immunity against these pathogens. According to e Silva et al. (52), probiotics tend to be unstable when they are near water environments. Contrary, environments and conditions where there is limited water have been shown to increases the stability of Lactobacillus species and probiotics. Water and moisture conductions can alter the PH and buffering systems of the environments occupied by pathogenic bacteria. Moreover, the sensitivity of probiotics to water conditions alters the re absorption efficiency and the retention time within the oral cavity, which in