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Sickle Cell Case Study Read the following case study and answer
the questions below. Provide evidence with correct citations to
support your answers.

V.M. is a 29 year old African American married man who has
sickle cell disease (SCD) marked by frequent episodes of severe
pain. His anemia has been managed with multiple transfusions. Six
months ago he started showing signs of chronic renal failure. His
regular medications are pentoxifylline (Trental),
oxycodone-acetaminophen (Percocet), hydroxyurea (Droxia), and folic
acid. In the hematology clinic this morning, V.M.’s hemoglobin
measured 6.7 g/dL. He received 2 units of packed red blood cells
(PRBCs) over 3 hours and went home. He developed dyspnea and
shortness of breath approximately 1 hour later, and his wife called
911. The emergency medical system crew initiated oxygen at 8 L per
nasal cannula and transported V.M. to the emergency department
(ED).

1. What is SCD?

2. True or False: Only African Americans get SCD. Explain your
response.

3. Which statement is true about the inheritance pattern of
SCD?

a. If V.M.’s wife has sickle cell trait, each child will either
have SCD or be a carrier.

b. If V.M.’s wife does not have sickle cell trait, each child
has a 50% risk of having SCD.

c. If V.M.’s wife has sickle cell trait, each child will either
have SCD or be normal.

d. If V.M. has children, each child will automatically have SCD
regardless of his wife’s status.

4. V.M.’s hemoglobin measured 6.7 g/dL. Why is anemia common in
patients with SCD?

5. Why is it difficult to crossmatch blood to transfuse
V.M.?

6. What role does hydroxyurea (Droxia) play in managing V.M.’s
SCD?