Patel, Patel, Dodiya and Shetal (26) stated that the buccal administration of drugs provided a convenient administration route for local drugs. Moreover, drugs fall in three different categories of drug delivery which constitute the sublingual, oral cavity and local routes. The permeability of the sublingual mucosa has been shown to enhance the rapid delivery of drugs for acceptable bioavailability in the body (maybe we should just remove this sentence because the aim of the thesis is local treatment ONLY in the oral cavity). Polshettiwar, Chopade, and Pande. (27) demonstrated the advantage of the buccal cavity as a drug delivery route where factors related to the large surface area of contact and transmucosal delivery were shown to facilitate drug delivery. The buccal route, therefore, serves as an important drug delivery route for drugs.
Probiotics as Essential Drivers in Drug Delivery
Probiotics refer to living organisms that are administered in large quantities for conferring health to the host organisms (4). Probiotics were applied traditionally to the gastrointestinal tract. The authors noted that the administration of probiotics increased the overall absorption of drugs (Do you mean other drugs ? because in this thesis probiotics is the active ingredient in the tablet – which means we want the effect of probiotics. But does this sentence mean, that If one takes probiotics it will increase the absorption of another drug ? Does the reference say how?) following oral route administration. Moreover, a study demonstrated the effects of probiotics in the treatment of several illnesses, including Crohn’s disease and acute diarrhoea (9).