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The PH of saliva, which is around neutral to slightly alkaline, also affects the stability of Lactobacillus. Moreover, the amount of water can dictate the PH of saliva. Ultimately, the amount of water in saliva can affect the stability of probiotics and Lactobacillus bacteria in the oral cavity (50). Nonetheless, the different formulations of probiotic agents can result in improved stability through embedding them in polymers and mucoadhesions to enhance the overall stability and shield them from the water effects. Govender, Choonara, Kumar, Toit, and Vuuren (50) added that probiotics were more viable and stable in gastric and acidic conditions compared to alkaline conditions which required much modification to enhance their stability in the basic environments. With the Kollidon 30 and the Manucol LKX polymers, the buffering effects of these polymers and their ability to absorb much water can serve as a drug modification technique for the enhanced stability of probiotics and delivery locally within the oral cavity.